August 6, 2007

Genomic Health Announces Second Quarter 2007 Financial Results and Business Progress

- Record Revenue and Continued Growth in Adoption and Reimbursement - - Additional 20 Million Lives Covered for Oncotype DX; More Than 145 Million Lives Covered through July 2007 - - Conference Call Today at 4:30 p.m. ET -

REDWOOD CITY, Calif., Aug 06, 2007 /PRNewswire-FirstCall via COMTEX News Network/ --

Genomic Health, Inc. (Nasdaq: GHDX) today reported financial results and business progress for the second quarter ended June 30, 2007.

Total revenue increased to $14.7 million in the second quarter of 2007 compared to $8.4 million in the second quarter of 2006. Product revenue from Oncotype DX(TM) was $14.6 million in the second quarter of 2007 compared to $7.8 million in the second quarter of 2006. Contract revenue was the balance of total revenue for each of these periods.

"Product revenue in the second quarter was stronger than our expectations, and we made important reimbursement progress," said Randy Scott, Ph.D., Chairman and Chief Executive Officer of Genomic Health. "We continued to expand and integrate our sales force for Oncotype DX, and we moved our clinical programs forward, which we believe will provide increasingly valuable individualized information to patients with breast cancer and other cancers."

Additional Second Quarter 2007 Financial Results

Cost of product revenue was $4.2 million in the second quarter of 2007 compared to $2.5 million for the second quarter of 2006. Research and development expenses for the second quarter of 2007 were $5.2 million compared to $2.7 million for the same period in 2006. Selling and marketing and general and administrative expenses for the second quarter of 2007 were $12.9 million compared to $8.6 million for the same period in 2006. Included in second quarter 2007 operating expenses was $1.5 million of stock-based compensation expense compared to $0.6 million in the same period in 2006.

Net loss was $7.2 million in the second quarter of 2007 compared to $4.9 million in the second quarter of 2006. Basic and diluted net loss per share applicable to common stockholders was $0.28 in the second quarter of 2007 compared to a net loss per share of $0.20 in the second quarter of 2006.

During the second quarter of 2007, approximately 34 percent of product revenue was recorded on an accrual basis and recognized at the time the test results were delivered, reflecting established payment patterns from payors with coverage policies in place.

Financial Results for Six Months Ended June 30, 2007

Total revenue for the six months ended June 30, 2007 was $28.8 million, compared to $13.4 million for the first six months of 2006. Product revenue for the six months ended June 30, 2007 was $27.7 million, compared to $12.0 million for the first six months of 2006. Contract revenue constituted the balance of revenue for the first six months of 2007 and 2006.

Cost of product revenue for the six months ended June 30, 2007 was $8.0 million, compared to $4.5 million for the comparable period in 2006. Research and development expenses for the first six months of 2007 were $10.4 million as compared to $5.4 million in the first six months of 2006. Selling and marketing, and general and administrative expenses for the first six months of 2007 were $25.2 million as compared to $16.3 million in the first six months of 2006. The increase in expenses includes stock-based compensation expense of $2.8 million in the first six months of 2007 compared to $1.2 million for the same period in 2006.

Net loss for the six months ended June 30, 2007 was $14.0 million, compared to $11.7 million for the first six months of 2006. Basic and diluted net loss per share was $0.55 for the six months ended June 30, 2007 compared to a net loss per share of $0.48 for the first six months of 2006.

Cash and Cash Equivalents

Cash and cash equivalents and investments at June 30, 2007 were $79.7 million compared to $44.2 million at December 31, 2006. The company completed a follow-on offering in May, 2007 of 3,450,000 shares, including the fully exercised over-allotment option, at $15.50 per share, resulting in approximately $49.7 million in net proceeds.

Financial Guidance

The company is reiterating its financial guidance for the full year ending December 31, 2007:

    -- Test results delivered: 23,000 to 25,000.
    -- Total revenue: $57 million to $63 million.  Given the strong revenue
       performance in the first half of 2007, management believes full year
       revenue may be at the high end of guidance.  Quarter to quarter
       fluctuation is expected in reported revenues.
    -- Net loss: $27 million to $30 million.


    Recent Highlights and Accomplishments

    Peer-Reviewed Publications and Medical Meeting Presentations

    -- Four abstracts were accepted for the 2007 ASCO Breast Cancer Symposium
       in September.
    -- A study conducted by Dr. Ruth Oratz et al., originally presented at the
       San Antonio Breast Cancer Symposium, was published in ASCO's Journal of
       Oncology Practice in July.  The study demonstrated that Oncotype DX
       Recurrence Score results influence treatment recommendations and use of
       chemotherapy in patients with early-stage breast cancer.
    -- Two Oncotype DX studies were presented at the 2007 ASCO meeting in
       June. The first suggested that Oncotype DX Recurrence Score results
       provide accurate recurrence risk information for patients with hormone
       receptor-positive breast cancer, regardless of whether they were
       node-negative or node-positive.  The second demonstrated that use of
       Recurrence Score results in a prospective, multi-center trial changed
       treatment decisions of both patients and physicians and increased
       confidence for a high proportion of patients.


    Physician Usage and Adoption

    -- More than 5,750 test results were delivered in the second quarter of
       2007 compared to more than 3,250 test results delivered in the second
       quarter of 2006.
    -- Over 6,000 physicians have ordered a cumulative total of more than
       33,000 tests for their patients since Oncotype DX became commercially
       available.
    -- We expanded our field sales team late in the second quarter to
       60 representatives, up from 40 representatives at the beginning of
       2007.
    -- We signed an exclusive agreement to distribute Oncotype DX in the
       United Kingdom with Medical Solutions plc, a healthcare and diagnostics
       business specializing in diagnostic pathology and cytology services and
       products.


    Reimbursement Progress for Oncotype DX

    -- Blue Cross Blue Shield of Michigan signed a contract covering
       approximately 4.7 million lives.
    -- Health Net signed a contract covering approximately 3.8 million lives.
    -- Independence Blue Cross (IBC) posted a positive reimbursement policy
       covering approximately 3.5 million lives.
    -- Blue Cross Blue Shield of Kansas posted a positive reimbursement policy
       covering approximately 900,000 lives.
    -- Health Partners, a regional plan covering approximately 750,000 lives,
       posted a positive reimbursement policy for Oncotype DX.  As part of an
       alliance with CIGNA HealthCare, Health Partners members will be covered
       under the CIGNA contract terms.
    -- The Blue Cross and Blue Shield Association's (BCBSA) Technology
       Evaluation Center (TEC) concluded that use of Genomic Health's Oncotype
       DX breast cancer assay to inform decision making about adjuvant
       chemotherapy meets the BCBSA TEC criteria for women with estrogen
       receptor-positive, node-negative, tamoxifen-treated breast cancer.
    -- Today, more than 145 million lives are covered by contracts,
       agreements and policy decisions for Oncotype DX.


    Pipeline

    -- Our study being conducted with the Southwest Oncology Group of Oncotype
       DX in node-positive breast cancer is ongoing.
    -- We completed two additional studies in our colon cancer program to
       enable the refinement of a final gene set and algorithm.  We expect to
       begin analytical validation work with the final gene set and algorithm
       in the second half of 2007, leading to a clinical validation study in
       2008, which if successful could be followed by a commercial launch in
       2009.
    -- We have begun a previously announced study using Oncotype DX in
       postmenopausal women with breast cancer who were treated with an
       aromatase inhibitor.  Aromatase inhibitors and tamoxifen are both used
       as standard treatment for early breast cancer patients with hormone
       receptor-positive disease.


    Regulatory

    -- On July 24, FDA posted new draft guidance on "In Vitro Diagnostic
       Multivariate Index Assays" that incorporates some stakeholder feedback
       and proposes a transition period of up to 18 months to obtain 510(k) or
       premarket approval for currently available tests.  Genomic Health is
       continuing its ongoing dialogue with FDA regarding the Oncotype DX
       breast cancer assay.


Conference Call Details

To access the live conference call today, August 6 at 4:30 p.m. Eastern Time via phone, please dial (877) 356-8064 from the United States and Canada or (706) 758-4314 internationally. The conference ID is 11540007. Please dial in approximately ten minutes prior to the start of the call. A telephone replay will be available beginning approximately one hour after the call through August 13 and may be accessed by dialing (800) 642-1687 from the United States and Canada or (706) 645-9291 internationally. The replay passcode is 11540007.

To access the live and subsequently archived webcast of the conference call, go to the Investor Relations section of the company's website at http://investor.genomichealth.com. Please connect to the web site at least 15 minutes prior to the call to allow for any software download that may be necessary.

About Genomic Health

Genomic Health, Inc. is a life science company focused on the development and commercialization of genomic-based clinical laboratory services for cancer that allow physicians and patients to make individualized treatment decisions. In 2004, Genomic Health launched its first test, Oncotype DX(TM), which has been shown to predict the likelihood of breast cancer recurrence and the likelihood of chemotherapy benefit in a large portion of early-stage breast cancer patients. The company was founded in 2000 and is located in Redwood City, California. For more information, please visit http://www.genomichealth.com.

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to our belief that we will be able to provide increasingly valuable information to patients with cancer; continued growth in adoption of and reimbursement for our test; the timing of a validation study or commercialization of our colon cancer assay; the outcome or success of clinical trials and our expectations regarding potential clinical outcomes; the applicability of clinical study results to actual outcomes; our expectations regarding our ASCO presentations; and our 2007 financial guidance, including expectations regarding the number of test results delivered, revenue, net loss and gross margin. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: our ability to increase usage of our tests; the risk that we may not obtain or maintain sufficient levels of reimbursement for our existing tests and any future tests we may develop; the risks and uncertainties associated with the regulation of our test by FDA; our ability to compete against third parties; our ability to develop and commercialize new tests; unanticipated costs or delays in research and development efforts; our ability to obtain capital when needed; our history of operating losses; the results of clinical studies and the other risks set forth in our filings with the Securities and Exchange Commission, including the risks set forth in our Quarterly Report on Form 10-Q for the quarter ended March 31, 2007. These forward-looking statements speak only as of the date hereof. Genomic Health disclaims any obligation to update these forward-looking statements

NOTE: Genomic Health, the Genomic Health logo, Oncotype, Oncotype DX and Recurrence Score are trademarks or registered trademarks of Genomic Health, Inc. All other trademarks and service marks are the property of their respective owners.

                         (Financial statements below)



                             Genomic Health, Inc.
               Condensed Consolidated Statements of Operations
               (in thousands, except share and per share data)

                                   For the Three             For the Six
                                       Months                   Months
                                   Ended June 30,           Ended June 30,
                                  2007        2006         2007       2006
                                     (Unaudited)             (Unaudited)

    REVENUES:
    Product revenues            $14,555      $7,815      $27,701     $12,005
    Contract revenues               135         564        1,077       1,434
    Total revenues               14,690       8,379       28,778      13,439

    OPERATING EXPENSES:
    Cost of product revenues      4,172       2,468        8,019       4,527
    Research and development      5,224       2,738       10,394       5,449
    Selling and marketing         8,740       5,806       16,893      10,901
    General and administrative    4,186       2,818        8,275       5,440
    Total operating expenses     22,322      13,830       43,581      26,317

    Operating loss               (7,632)     (5,451)     (14,803)    (12,878)


    Other income (expense):
    Interest income                 608         646        1,124       1,338
    Interest expense               (178)       (113)        (373)       (208)
    Other income                      4           3            4           3


    Net loss                    ($7,198)    ($4,915)    ($14,048)   ($11,745)

    Basic and diluted net
     loss per share              ($0.28)     ($0.20)      ($0.55)     ($0.48)

    Shares used to compute
     basic and diluted net
     loss per share          26,141,476  24,500,912   25,355,685  24,490,432



                             Genomic Health, Inc.
                    Condensed Consolidated Balance Sheets
                                (in thousands)

                                                      As of        As of
                                                    30-Jun-07    31-Dec-06
                                                   (Unaudited)   (Audited)
    Cash and cash equivalents                        $43,573      $14,926
    Short-term investments                            36,108       29,289
    Accounts receivable                                3,033        1,862
    Prepaid expenses and other current assets          3,235        1,609
    Total current assets                              85,949       47,686

    Property and equipment, net                        9,866        9,421
    Restricted cash                                      500          500
    Other assets                                         516          417
    Total assets                                     $96,831      $58,024

    Accounts payable                                  $1,292       $2,523
    Accrued expenses and other current liabilities     6,662        4,390
    Deferred revenue                                     882          847
    Capital leases, current                            2,689        2,547
    Capital leases, long-term                          3,345        4,726
    Other liabilities                                  1,404        1,162
    Stockholders' equity                              80,557       41,829
    Total liabilities and stockholders' equity       $96,831      $58,024


    The condensed consolidated balance sheet at December 31, 2006 has been
    derived from the audited consolidated financial statements at that date
    included in the Company's Form 10-K for the fiscal year ended December 31,
    2006.


SOURCE Genomic Health, Inc.

Brad Cole, +1-650-569-2281, investors@genomichealth.com, or Media, Emily Faucette,
+1-650-569-2824, media@genomichealth.com, both of Genomic Health, Inc.
http://www.genomichealth.com

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