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Genomic Health Announces New Evidence Further Demonstrating Clinical Utility and Cost-Effectiveness of Oncotype DX in Colon Cancer
Additionally, the company announced that the
"These new data reinforce the value of an individualized recurrence risk assessment score that enables physicians to identify those at high risk of recurrence who can experience a greater potential benefit from chemotherapy, as well as patients with a low risk of recurrence who can be spared unnecessary treatment," said
Oncotype DX Colon Cancer Test Changes 45 Percent of Treatment Decisions
"Current clinical practice reveals a high level of variability and subjectivity in the treatment of stage II colon cancer patients," said
Conducted in collaboration with the
Mayo Clinic Cancer Research Consortium, a prospectively designed study analyzed treatment decisions for 141 stage II, T3 MMR-proficient colon cancer patients across 17 sites demonstrating that the use of the Oncotype DX Colon Cancer test changed treatment decisions 45 percent of the time and led to an overall reduction in chemotherapy use.
For patients whose treatment recommendations changed, treatment intensity decreased for more than 33 percent of patients (from chemotherapy to observation or from oxaliplatin-containing to non-oxaliplatin containing regimens) and increased for more than 11 percent of patients (from observation to any chemotherapy or from non-oxaliplatin containing to oxaliplatin-containing treatment).
Abstract #453: "Prospective evaluation of a 12-gene assay on treatment recommendations in stage II colon cancer patients" will be presented on
Second Health Economics Study Reconfirms Test's Cost Effectiveness
An analysis of 141 patients from 17 sites in the
Mayo Clinic Cancer Research Consortiumdemonstrated the value of using the Oncotype DX test to identify stage II colon cancer patients with low risk of recurrence. After receiving the Recurrence Score results, physician recommendations for adjuvant chemotherapy in patients with low risk of recurrence decreased by 22 percent, which resulted in direct medical care costs savings of $4,200per patient.
This is the first health economic study of the Oncotype DX Colon Cancer test conducted in clinical practice. A separate modeling study showing that the use of the Oncotype DX test in stage II colon cancer patients may lead to health care cost savings while improving clinical outcomes was recently published in the
Abstract #391: "Real-world comparative economics of a 12-gene assay for prognosis in stage II colon cancer" will be presented on
Additionally, a poster titled: "Impact of the Recurrence Score (RS) result and mismatch repair status (MMR) on agreement between oncologists (MDs) for stage II colon cancer (CC) recurrence risk (RR) assessment: A novel clinical utility endpoint for prognostic markers" (Abstract #349) will be presented on Saturday, January 26, from 7:00 - 7:55 a.m. Pacific Time at Moscone West, San Francisco, Calif.
Four leading medical specialty societies co-sponsor the three-day, multidisciplinary symposium, including the
About Genomic Health
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the ability of the company's colon cancer test to impact treatment decisions in a clinical setting; the ability of test to reduce the use of chemotherapy and the direct medical costs associated with treating colon cancer; the potential of the company's test to change medical practice in the treatment of stage II or stage III colon cancer; the ability of the company to secure additional reimbursement for its colon cancer test; the applicability of study results to clinical practice; the timing and results of future studies or clinical trials; the focus and attributes of the company's product pipeline; the ability of the company to develop additional tests in the future; and the ability of any potential tests the company may develop to optimize cancer treatment. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the applicability of clinical study results to actual outcomes; the risks and uncertainties associated with possible additional regulation of the company's tests both in
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